When I first started investigating ADHD and PMDD, I never expected DNA testing to become such a powerful tool in understanding my body. However, after years of struggling with overwhelm, emotional dysregulation, and severe premenstrual symptoms, I decided to take a scientific approach to managing my health.
- There’s No Single “ADHD Gene”
- Self-Diagnosed at 35: Understanding My Brain
- Key DNA Findings and How They Impacted My ADHD & PMDD
- Using Science to Personalize My Health
- Final Thoughts: Why DNA Testing Was a Game-Changer
There’s No Single “ADHD Gene”
It is a common misconception that a single gene determines whether someone has ADHD. In reality, ADHD is polygenic, meaning it is influenced by hundreds of genetic variants that impact dopamine regulation, executive function, and neurotransmitter metabolism. Research has identified multiple genes associated with ADHD, including DRD4, DAT1, COMT, and SNAP25, all of which play a role in dopamine signaling and brain function (Faraone et al., 2015).
Similarly, PMDD is not caused by a single mutation but rather by an abnormal sensitivity to normal hormonal fluctuations, particularly estrogen and progesterone, which impact serotonin and GABA levels (Epperson et al., 2012). This hormonal sensitivity can exacerbate mood symptoms in women with underlying ADHD, making late-cycle symptoms significantly more severe (Quinn, 2003).
For me, DNA testing wasn’t about diagnosing ADHD or PMDD—it was about identifying the genetic factors affecting my neurotransmitters, metabolism, and hormone regulation, so I could tailor my supplements, diet, and lifestyle accordingly.
Self-Diagnosed at 35: Understanding My Brain
I was diagnosed with ADHD at 35, although I had struggled with the symptoms my entire life. I often hyperfocused on projects, abandoned them, and started new ones. I lived in a state of constant overwhelm and burnout, a hallmark of ADHD in women (Quinn, 2003).
PMDD compounded my difficulties. The two weeks before my period were the hardest—with mood swings, extreme anxiety, and difficulty regulating emotions. Research shows that women with ADHD experience more severe PMS and PMDD symptoms, due to the interaction between dopamine dysregulation and hormonal fluctuations (Ordóñez et al., 2020).
That’s when I decided to take a data-driven approach and examine my genetic predispositions through DNA testing.
Key DNA Findings and How They Impacted My ADHD & PMDD
1. MTHFR Gene Mutation and Methylation Issues
One of the most critical findings in my DNA test was a MTHFR gene mutation, which affects how my body processes folate (B9) and vitamin B12. These nutrients are essential for dopamine production and hormone metabolism, meaning deficiencies can worsen ADHD symptoms and PMDD mood swings (Ramos et al., 2007).
What I’m Doing About It
- Taking methylated B vitamins (methylfolate & methylcobalamin) instead of synthetic folic acid.
- Eating leafy greens, eggs, and liver for natural sources of B vitamins.
- Avoiding processed foods with synthetic folic acid, which my body struggles to process.
2. Dopamine and Motivation Genes (COMT & DRD2)
Dopamine is known as the motivation molecule. Low dopamine levels are a hallmark of ADHD, leading to issues with focus, impulse control, and task persistence. My DNA results showed variations in COMT and DRD2 genes, which impact dopamine metabolism and receptor sensitivity (Volkow et al., 2005).
What I’m Doing About It
- Taking L-tyrosine, a dopamine precursor, to support focus and motivation (Mason et al., 2013).
- Exercising daily (HIIT, strength training, and boxing) to naturally increase dopamine (Weyandt et al., 2020).
- Using cold therapy (cold showers, ice baths), which has been shown to boost dopamine levels (Niemann et al., 2021).
3. Histamine Intolerance (DAO & HNMT Genes)
Histamine intolerance is often overlooked in ADHD and PMDD, yet it affects mood, focus, and inflammation levels. My DNA results showed genetic variants that impair histamine breakdown, leading to brain fog, anxiety, and increased PMS symptoms (Maintz & Novak, 2007).
What I’m Doing About It
- Eating low-histamine foods (avoiding aged cheese, wine, and fermented foods).
- Taking DAO enzyme supplements before histamine-rich meals.
- Drinking quercetin-rich teas (like chamomile) to support histamine metabolism.
4. Estrogen Detox Pathways (CYP1A1 & CYP3A4 Genes)
PMDD is strongly linked to poor estrogen metabolism, meaning some women experience higher estrogen levels for longer periods, contributing to mood swings and increased sensitivity to hormonal changes (Rubinow et al., 2016). My DNA test revealed slow estrogen detox pathways, making it harder for my body to break down excess hormones.
What I’m Doing About It
- Eating cruciferous vegetables (broccoli, Brussels sprouts) to support estrogen detox.
- Taking DIM (Diindolylmethane) supplements, which help process estrogen efficiently (Zeligs, 2019).
- Using infrared sauna therapy to support liver detoxification.
5. Omega-3 Processing (FADS1 Gene)
Omega-3 fatty acids are essential for brain function and mood regulation, but some genetic variations affect how efficiently the body converts plant-based omega-3s (ALA) into usable EPA & DHA (Simopoulos, 2011). My DNA results showed a variation in the FADS1 gene, indicating that my conversion rate is low.
What I’m Doing About It
- Taking high-dose omega-3 fish oil (4000 mg per day) to support ADHD and PMDD symptoms (Hirayama et al., 2004).
- Eating wild-caught salmon and sardines multiple times per week.
- Avoiding vegetable oils (canola, soybean) that interfere with omega-3 absorption.
Using Science to Personalize My Health
Since getting my DNA test results, I have completely transformed how I approach my ADHD and PMDD management. Instead of trial and error, I now rely on data-driven strategies to:
- Personalize my supplements and nutrition
- Optimize exercise routines for dopamine regulation
- Manage hormone balance based on my genetic detox pathways
- Reduce brain fog, mood swings, and PMDD flare-ups
Which DNA Test Do I Recommend?
If you’re considering DNA testing to gain insights into your neurotransmitter function, hormone metabolism, and nutrient processing, I highly recommend using DNA LIFE. The key features I looked for in a DNA test included:
- Comprehensive genetic analysis for ADHD-related pathways (dopamine, serotonin, and methylation genes).
- Hormone metabolism insights, especially for estrogen detox pathways.
- Personalized health reports with actionable recommendations.
- Nutrigenomics focus, helping tailor diet and supplements based on genetic findings.
My preferred test provided detailed insights into how my body processes neurotransmitters, detoxifies hormones, and responds to key nutrients. This helped me eliminate trial and error and make targeted changes to my diet, supplementation, and lifestyle.
Get your OWN DNA Test (no matter where you are in the world.) More information here.
Final Thoughts: Why DNA Testing Was a Game-Changer
If you are struggling with ADHD, PMDD, or other chronic health issues, I highly recommend considering DNA testing. While it will not diagnose ADHD or PMDD, it can provide valuable insights into your body’s unique genetic profile—allowing you to make targeted lifestyle and supplement changes that support your well-being.
References
Epperson, C. Neill, et al. “Premenstrual Dysphoric Disorder: Evidence for a Distinct Clinical Entity.” American Journal of Psychiatry 169, no. 5 (2012): 459–68.
Faraone, Stephen V., et al. “The Genetics of ADHD: A Review.” Molecular Psychiatry 20, no. 3 (2015): 289–97.
Mason, Graeme F., et al. “The Effects of Tyrosine Supplementation on Dopamine Function in ADHD.” Neuropsychopharmacology 38, no. 2 (2013): 276–84.
Quinn, Patricia O. “Attention Deficit Disorder in Women.” Journal of Clinical Psychology 59, no. 1 (2003): 119–30.
Volkow, Nora D., et al. “Dopamine in ADHD.” Biological Psychiatry 57, no. 11 (2005): 1410–15.
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